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Results for "

Inhibitor Kit/Phosphat ASe_ Inhibitor _Cocktail_I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Kit (91) Akt (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (31) Aurora Kinase (2) Autophagy (23) Bcr-Abl (14) c-Fms (16) c-Met/HGFR (9) c-Myc (1) Casein Kinase (1) CDK (1) Checkpoint Kinase (Chk) (1) Discoidin Domain Receptor (3) Drug Metabolite (11) Drug-Linker Conjugates for ADC (2) E3 Ligase Ligand-Linker Conjugates (1) EGFR (3) Elastase (2) Epigenetic Reader Domain (2) FAK (1) Ferroptosis (3) FGFR (22) FLT3 (25) Histone Acetyltransferase (1) IKK (1) Isotope-Labeled Compounds (7) JAK (1) Ligands for E3 Ligase (1) Na+/K+ ATPase (1) NAMPT (1) NO Synthase (1) PDGFR (65) PDK-1 (1) Pim (1) PKA (1) PKC (2) PROTACs (1) RAD51 (2) Raf (10) RET (16) SARS-CoV (4) Small Interfering RNA (siRNA) (3) Src (7) Syk (1) TAM Receptor (4) Tie (3) Trk Receptor (3) VEGFR (55) Wnt (1)
By Research Areas:	Cancer (122) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (14) Neurological Disease (2)

By Targets:

c-Kit (91)

Akt (2)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (31)

Aurora Kinase (2)

Autophagy (23)

Bcr-Abl (14)

c-Fms (16)

c-Met/HGFR (9)

c-Myc (1)

Casein Kinase (1)

CDK (1)

Checkpoint Kinase (Chk) (1)

Discoidin Domain Receptor (3)

Drug Metabolite (11)

Drug-Linker Conjugates for ADC (2)

E3 Ligase Ligand-Linker Conjugates (1)

EGFR (3)

Elastase (2)

Epigenetic Reader Domain (2)

FAK (1)

Ferroptosis (3)

FGFR (22)

FLT3 (25)

Histone Acetyltransferase (1)

IKK (1)

Isotope-Labeled Compounds (7)

JAK (1)

Ligands for E3 Ligase (1)

Na+/K+ ATPase (1)

NAMPT (1)

NO Synthase (1)

PDGFR (65)

PDK-1 (1)

Pim (1)

PKA (1)

PKC (2)

PROTACs (1)

RAD51 (2)

Raf (10)

RET (16)

SARS-CoV (4)

Small Interfering RNA (siRNA) (3)

Src (7)

Syk (1)

TAM Receptor (4)

Tie (3)

Trk Receptor (3)

VEGFR (55)

Wnt (1)

By Research Areas:

Cancer (122)

Cardiovascular Disease (3)

Infection (1)

Inflammation/Immunology (14)

Neurological Disease (2)

146

Inhibitors & Agonists

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: c-Kit

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-104068

Naphthol AS-E	Histone Acetyltransferase Epigenetic Reader Domain	Cancer
Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (K_d:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC₅₀ of 2.26 µM. Naphthol AS-E can be used for cancer research.

HY-15240

c-Kit-IN-1

c-Kit c-Met/HGFR Cancer

c-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC₅₀s of <200 nM.

*c-Kit-IN-1*	c-Kit c-Met/HGFR	Cancer
c-Kit-IN-1 is a potent inhibitor of *c-Kit* and c-Met with IC₅₀s of <200 nM.

HY-18302

*c-Kit-IN-5-1*	c-Kit	Inflammation/Immunology
c-Kit-IN-5 is potent inhibitor of *c-Kit, with IC₅₀s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit* over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .

HY-101034

*CHMFL-ABL/KIT-155* CHMFL-ABL-Kit-155
CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC₅₀s of 46 nM and 75 nM, respectively), and it also presents significant inhibitory activities to BLK (IC₅₀=81 nM), CSF1R (IC₅₀=227 nM), DDR1 (IC₅₀=116 nM), DDR2 (IC₅₀=325 nM), LCK (IC₅₀=12 nM) and PDGFRβ (IC₅₀=80 nM) kinases. CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155) arrests cell cycle progression and induces apoptosis .

HY-128589

CHMFL-KIT-033

c-Kit Cancer

CHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC₅₀ of 0.045 μM .

*CHMFL-KIT-033*	c-Kit	Cancer
CHMFL-KIT-033 is a potent and selective inhibitor of *c-KIT* T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC₅₀** of 0.045 μM .

HY-128602

*c-Kit-IN-2*	c-Kit	Cancer
c-Kit-IN-2 is a *c-KIT* inhibitor with an IC₅₀ of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI₅₀s of 3, 1, and 2 nM, respectively .

HY-132451S

(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit	Isotope-Labeled Compounds	Others
(R,S)-4-Hydroxy Cyclophosphamide-d₄ Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit[1].

HY-RS07319

KIT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KIT Human Pre-designed siRNA Set A contains three designed siRNAs for KIT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KIT Human Pre-designed siRNA Set A KIT Human Pre-designed siRNA Set A

HY-RS07320

Kit Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kit Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kit gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kit Mouse Pre-designed siRNA Set A Kit Mouse Pre-designed siRNA Set A

HY-RS07321

Kit Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kit Rat Pre-designed siRNA Set A contains three designed siRNAs for Kit gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kit Rat Pre-designed siRNA Set A Kit Rat Pre-designed siRNA Set A

HY-KT001

E3 Ligase Ligand-Linker Conjugate Kit	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-Linker Conjugate Kit is a series of synthesized compounds that incorporate an E3 ligase ligand and a linker used in PROTAC technology.

HY-P99462

Barzolvolimab CDX 0159	c-Kit	Inflammation/Immunology
Barzolvolimab (CDX 0159) is a humanized anti-KIT IgG1 monoclonal antibody. Barzolvolimab specificity and potently inhibits KIT activation by SCF. Barzolvolimab can reduce skin mast cells and disease activity in chronic inducible urticaria .

HY-145557

Bezuclastinib CGT9486; PLX 9486	c-Kit	Cancer
Bezuclastinib (CGT9486) is an orally active, highly selective tyrosine kinase inhibitor with potent activity against KIT D816V. Bezuclastinib can be used for the research of nonadvanced systemic mastocytosis (NonAdvSM) .

HY-18317

JNJ-38158471	VEGFR RET c-Kit	Cancer
JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC₅₀ of 40 nM. JNJ-38158471 also inhibits Ret and *Kit* with IC₅₀s of 180 and 500 nM, respectively .

HY-15198

KG5	Raf PDGFR FLT3 c-Kit	Cancer
KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor. KG5 also inhibits Flt3, *KIT* and c-Raf. KG5 has anticancer, antiangiogenic activities .

HY-103299

KG-501

10+ Cited Publications

Naphthol AS-E Phosphate
Epigenetic Reader Domain Inflammation/Immunology

KG-501 is a CREB inhibitor, with an IC₅₀ of 6.89 μM.
HY-N11690

Oleandrigenin

Na+/K+ ATPase Cardiovascular Disease Cancer

Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

KG-501 10+ Cited Publications Naphthol AS-E Phosphate	Epigenetic Reader Domain	Inflammation/Immunology
KG-501 is a CREB inhibitor, with an IC₅₀ of 6.89 μM.

Oleandrigenin	Na+/K+ ATPase	Cardiovascular Disease Cancer
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-139996

Pomalidomide-C5-Dovitinib	PROTACs Ligands for E3 Ligase	Cancer
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD ⁺ acute myeloid leukemia .

HY-132166

M4205

c-Kit Cancer

M4205 is a c-KIT inhibitor, with an IC₅₀ of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.
HY-112802

AZD3229

c-Kit Cancer

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

M4205	c-Kit	Cancer
M4205 is a *c-KIT* inhibitor, with an IC₅₀ of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.

AZD3229	c-Kit	Cancer
AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC₅₀ value of 223.3 nM .

HY-101443

ISCK03 2 Publications Verification	c-Kit	Inflammation/Immunology
ISCK03 is a *SCF/c-Kit* and CD117-specific inhibitor. ISCK03 significantly inhibits c-Kit phosphorylation at 10 μM .

HY-16961

Sitravatinib 1 Publications Verification MGCD516; MG-516	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-16961A

Sitravatinib malate MGCD516 malate; MG-516 malate	VEGFR c-Kit FLT3 Discoidin Domain Receptor Trk Receptor	Inflammation/Immunology Cancer
Sitravatinib malate (MGCD516 malate) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC₅₀s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively . Sitravatinib malate shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment .

HY-15652

Freselestat ONO-6818; ONO-PO-736	Elastase	Inflammation/Immunology
Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity .

HY-156619

Labuxtinib

c-Kit Cancer

Labuxtinib is c-kit tyrosine kinase inhibitor .

Labuxtinib	c-Kit	Cancer
Labuxtinib is c-kit tyrosine kinase inhibitor .

HY-15652A

Freselestat quarterhydrate ONO-6818 quarterhydrate; ONO-PO-736 quarterhydrate	Elastase	Inflammation/Immunology
Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat quarterhydrate is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat quarterhydrate has a potent anti-inflammatory activity .

HY-10873

N-Desethyl Sunitinib 5 Publications Verification SU-12662	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and *KIT* inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-138813

N-Desethyl Sunitinib hydrochloride 5 Publications Verification SU-12662 hydrochloride	Drug Metabolite	Cancer
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and *KIT* inhibitor with K_i values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .

HY-112452

SU11652	VEGFR FGFR PDGFR c-Kit Apoptosis	Cancer
SU11652 is a potent receptor tyrosine kinase (RTK) inhibitor. SU11652 also inhibits several members of the split kinase family of RTKs, including VEGFR, FGFR, PDGFR, and *Kit. SU11652 can be uesd for spontaneous cancers expressing Kit* mutations research .

HY-112802A

AZD3229 Tosylate

c-Kit Cancer

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

AZD3229 Tosylate	c-Kit	Cancer
AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

HY-13838

PLX647	c-Fms c-Kit	Cancer
PLX647 is an orally active, highly specific dual FMS and *KIT* kinase inhibitor, with IC₅₀s of 28 and 16 nM, respectively. PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC₅₀s=91 and 130 nM, respectively) .

HY-10873S

N-Desethyl Sunitinib-d5	Isotope-Labeled Compounds Drug Metabolite	Cancer
N-Desethyl Sunitinib-d₅ is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].

HY-13838A

PLX647 dihydrochloride	c-Fms c-Kit	Inflammation/Immunology Cancer
PLX647 dihydrochloride is an orally active, highly specific dual FMS and *KIT* kinase inhibitor, with IC₅₀s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC₅₀s=91 and 130 nM, respectively) .

HY-50946

Imatinib Mesylate 65+ Cited Publications STI571 Mesylate; CGP-57148B Mesylate	c-Kit Bcr-Abl PDGFR Autophagy	Cancer
Imatinib Mesylate (STI571 Mesylate) is a tyrosine kinases inhibitor that inhibits *c-Kit, Bcr-Abl, and PDGFR* (IC₅₀=100 nM) tyrosine kinases.

HY-112616

NAMPT inhibitor-linker 2	NAMPT Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 2 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-4 consists of an NAMPT inhibitor-linker 2 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC₅₀s of <7 pM and 40 pM, respectively.

HY-G0017

N-Desmethyl imatinib Norimatinib; Imatinib metabolite N-Desmethyl imatinib	Drug Metabolite	Others
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-G0017A

N-Desmethyl imatinib mesylate Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate	Drug Metabolite	Others
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-110071

APcK110

c-Kit Cancer

APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis .

APcK110	c-Kit	Cancer
APcK110 is a potent *Kit* inhibitor that can be used for the research of acute myeloid leukemia (AML). APcK110 induces AML cell apoptosis .

HY-112615

NAMPT inhibitor-linker 1	Drug-Linker Conjugates for ADC	Cancer
NAMPT inhibitor-linker 1 is a agent-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC₅₀s of <3 pM and 9 pM, respectively.

HY-16749A

Pexidartinib hydrochloride 65+ Cited Publications PLX-3397 hydrochloride	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and *c-Kit* inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .

HY-10209

Masitinib 5 Publications Verification AB1010	c-Kit PDGFR Src FGFR FAK Apoptosis	Cancer
Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of *c-Kit* (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity .

HY-10209A

Masitinib mesylate 5 Publications Verification AB-1010 mesylate	c-Kit PDGFR Src FGFR Apoptosis	Cancer
Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of *c-Kit* (IC₅₀=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC₅₀s=540/800 nM), Lyn (IC₅₀= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib mesylate (AB-1010 mesylate) has anti-proliferative, pro-apoptotic activity and low toxicity .

HY-101561

Avapritinib 5 Publications Verification BLU-285	c-Kit PDGFR	Cancer
Avapritinib (BLU-285) is a highly potent, selective, and orally active *KIT* and PDGFRA activation loop mutant kinases inhibitor with IC₅₀s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 .

HY-10501

SU14813 1 Publications Verification	PDGFR VEGFR c-Kit	Cancer
SU14813 is a multi-targeted receptor tyrosine kinases inhibitor with IC₅₀s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and *KIT*.

HY-10501A

SU14813 maleate 1 Publications Verification	PDGFR VEGFR c-Kit	Cancer
SU14813 maleate is a multi-targeted receptor tyrosine kinases inhibitor with IC₅₀s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and *KIT*.

HY-16749

Pexidartinib 65+ Cited Publications PLX-3397	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and *c-Kit* inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .

HY-10527

Telatinib 1 Publications Verification Bay 57-9352	c-Kit PDGFR VEGFR	Cancer
Telatinib (Bay 57-9352) is an orally active, small molecule inhibitor of VEGFR2, VEGFR3, PDGFα, and *c-Kit* with IC₅₀s of 6, 4, 15 and 1 nM, respectively.

HY-10527C

Telatinib mesylate 1 Publications Verification Bay 57-9352 mesylate	VEGFR PDGFR c-Kit	Cancer
Telatinib mesylate (Bay 57-9352 mesylate) is a potent and orally active VEGFR2, VEGFR3, PDGFα, and *c-Kit* inhibitor with IC₅₀s of 6 nM, 4 nM, 15 nM and 1 nM, respectively .

HY-148794

Risvodetinib IkT-148009	c-Met/HGFR	Cancer
Risvodetinib is a potent protein tyrosine kinase inhibitor. Risvodetinib involves in synthesis of Abelson protein kinases (c-Abl1, c-Abl2, and c-kit) inhibitor .

HY-18179

AZD2932	PDGFR VEGFR FLT3 c-Kit	Cancer
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3 and *c-Kit* with IC₅₀s of 8, 4, 7 and 9 nM in cell assay, respectively.

Cat. No.	Product Name

HY-K0021

Phosphatase Inhibitor Cocktail I 350+ Cited Publications
Phosphatase Inhibitor Cocktail I effectively inhibits alkaline phosphatases and serine/threonine protein phosphatases such as PP1 and PP2A.

HY-K0301

*Cell Counting Kit-8* Maximum Cited Publications 2187 Publications Verification
Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.

HY-K1090

Cytotoxicity LDH Assay Kit 4 Publications Verification
MCE Cytotoxicity LDH Assay Kit can detect LDH activity in the culture supernatant, which is indicative of cytotoxicity. Meanwhile viable cell number can be detected by CCK8 Kit (HY-K0301).

HY-K1078

*One Step TUNEL Apoptosis Detection Kit* (FITC)**
MCE One Step TUNEL Apoptosis Detection Kit (FITC) provides a rapid and convenient method to detect cell apoptosis. After staining cells with this kit, live cells have no fluorescence, apoptosis cells show green fluorescence.

HY-K1079

*One Step TUNEL Apoptosis Detection Kit* (Cyanine 3)** 1 Publications Verification
MCE One Step TUNEL Apoptosis Detection Kit (Cyanine 3) provides a rapid and convenient method to detect cell apoptosis. After staining cells with this kit, live cells have no fluorescence, apoptosis cells show red fluorescence.

HY-K1082

Viral DNA/RNA Mini Purification Kit
MCE Viral DNA/RNA Mini Purification Kit allows rapid and efficient purification of viral DNA/RNA based on the selective binding of DNA/RNA to the silica-based membrane. Viral DNA/RNA purified with this kit can be used for PCR, RT-PCR, qPCR, and qRT-PCR.

HY-K1070

Apoptosis and Necrosis Assay Kit

1 Publications Verification

MCE Apoptosis and Necrosis Assay Kit provides a rapid and convenient method to detect cell apoptosis and necrosis.

HY-K1072

*Cell Apoptosis Analysis Kit* (Hoechst staining)** 1 Publications Verification
MCE Cell Apoptosis Analysis Kit (Hoechst staining) provides a rapid and convenient method to detect cell apoptosis.

HY-K1071

*Cell Cycle and Apoptosis Analysis Kit* (PI staining)** 4 Publications Verification
MCE Cell Cycle and Apoptosis Analysis Kit (PI staining) provides a convenient method to detect cell cycle and cell apoptosis.

HY-K1061

*Mitochondria Isolation Kit* for Tissue**
MCE Mitochondria Isolation Kit for Tissue enables the fast and efficient isolation of intact mitochondria from tissue using differential centrifugation.

HY-K1060

*Mitochondria Isolation Kit* for Cultured Cells** 4 Publications Verification
MCE Mitochondria Isolation Kit for Cultured Cells enables the fast and efficient isolation of intact mitochondria from cells using differential centrifugation.

HY-K1005

Ultra High Sensitivity ECL Kit 45+ Cited Publications
MCE Ultra High Sensitivity ECL Kit is an ultra-sensitive, luminol-based enhanced chemiluminescent substrate for detecting horseradish peroxidase (HRP) labeled antibodies on western blots.

HY-K0302

Cell-ATP Viability Detection Kit
MCE Cell-ATP Viability Detection Kit is used for detecting the number and viability of living cells in culture based on high-sensitivity bioluminescence detection technology of the ATP present.

HY-K0304

Human CD3+ T Cells Negative Selection Kit
MCE Human CD3⁺ T Cells Negative Selection Kit is designed for the isolation of CD3⁺ T cells from human peripheral blood mononuclear cells (PBMC).

HY-K0510A

RT Master Mix for qPCR II 50+ Cited Publications
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription. With advanced reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K1013

Renilla-Firefly Luciferase Dual Assay Kit 5+ Cited Publications
MCE Renilla-Firefly Luciferase Dual Assay Kit is designed to be used for high-throughput, rapid quantitation of both Firefly and Renilla luciferases from a single sample in mammalian cell culture.

HY-K0310

Mouse CD8⁺ Cell Positive Selection Kit
MCE Mouse CD8⁺ Cells Positive Selection Kit is designed for the isolation of CD8⁺ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

HY-K0601

JC-1 Mitochondrial Membrane Potential Assay Kit 40+ Cited Publications
MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

HY-K0308

Mouse CD4+ Cell Positive Selection Kit
MCE Mouse CD4⁺ T Cells Positive Selection Kit is designed for the isolation of CD4⁺ cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

HY-K1063

*Exosome Isolation and Purification Kit* (from plasma and serum)**
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from plasma and serum that can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

HY-K2006

Sensitive ECL Kit 1 Publications Verification
Sensitive ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems.

HY-K0306

Mouse CD3+ T Cells Negative Selection Kit
MCE Mouse CD3⁺ T Cells Negative Selection Kit is designed for the isolation of CD3⁺ T cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

HY-K0307

Mouse CD4+ T Cells Negative Selection Kit
MCE Mouse CD4⁺ T Cells Negative Selection Kit is designed for the isolation of CD4⁺ T cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

HY-K0309

Mouse CD8+ T Cells Negative Selection Kit
MCE Mouse CD8⁺ T Cells Negative Selection Kit is designed for the isolation of CD8⁺ T cells from single cell suspensions of mouse spleen cells, lymph nodes or other tissues.

HY-K0305

Human CD34+ Cells Negative Selection Kit
MCE Human CD34⁺ Cells Negative Selection Kit is designed for the isolation of CD34⁺ cells from human cord blood mononuclear cells (CBMC) or human peripheral blood mononuclear cells (PBMC).

HY-K1062

*Exosome Isolation and Purification Kit* (from cell culture media)**
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from cell culture media that can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

HY-K2005

High Sensitivity ECL Kit 1 Publications Verification
High Sensitivity ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems.

HY-K1076

Annexin V-mCherry Apoptosis Detection Kit
Annexin V-mCherry Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.

HY-K1064

*Exosome Protein Detection Kit* (CD63 & TSG101)**
MCE Exosome Protein Detection Kit (CD63&TSG101) can specifically detect exosome proteins CD63 and TSG101. This product is suitable for the detection of human, rat and mouse exosomes.

HY-K1075

Annexin V-PE Apoptosis Detection Kit
MCE Annexin V-PE Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells and necrosis cells show red fluorescence.

HY-K6106

Human Cholangiocarcinoma Organoid Kit
MCE Human Cholangiocarcinoma Organoid Kit contains Cholangiocarcinoma Organoid Basal Medium A, Cholangiocarcinoma Organoid Supplement B (50x), Cholangiocarcinoma Organoid Supplement C (250x). This product can be used to efficiently construct human cholangiocarcinoma organoid.

HY-K0511A

RT Master Mix for qPCR II (gDNA digester plus) 10+ Cited Publications
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K1084

VF 647 Click-iT EdU Universal Cell Proliferation Detection Kit
MCE VF 647 Click-iT EdU Universal Cell Proliferation Detection Kit contains EdU and VF 647 Azide dye, along with the catalysts and buffers required for click chemistry. It can be used for simple, rapid, efficient and sensitive cell proliferation assays.

HY-K1085

VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit
MCE VF 594 Click-iT EdU Universal Cell Proliferation Detection Kit contains EdU and VF 594 Azide dye, along with the catalysts and buffers required for click chemistry. It can be used for simple, rapid, efficient and sensitive cell proliferation assays.

HY-K1087

VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit
MCE VF 488 Click-iT EdU Universal Cell Proliferation Detection Kit contains EdU and VF 488 Azide dye, along with the catalysts and buffers required for click chemistry. It can be used for simple, rapid, efficient and sensitive cell proliferation assays.

HY-K1086

VF 555 Click-iT EdU Universal Cell Proliferation Detection Kit
MCE VF 555 Click-iT EdU Universal Cell Proliferation Detection Kit contains EdU and VF 555 Azide dye, along with the catalysts and buffers required for click chemistry. It can be used for simple, rapid, efficient and sensitive cell proliferation assays.

HY-K1065

*Exosome Isolation and Purification Kit* (from body fluids)**
MCE Exosome Isolation and Purification Kit provides a simple and effective method to isolate and purify intact exosomes from cerebro-spinal fluid, amniotic fluid, milk, saliva, etc, which can be used for electron microscope analysis, NTA analysis, WB, qPCR, etc.

HY-K1077

Annexin V-mCherry/SYTOX Green Apoptosis Detection Kit
Annexin V-mCherry/SYTOX Green Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence, apoptosis cells show red fluorescence, necrosis cells show red and green fluorescence.

HY-K6115

Human Pancreatic Organoid Kit
MCE Human Pancreatic Organoid Kit contains Human Pancreatic Organoid Basal Medium A, Human Pancreatic Organoid Supplement B (50x), and Human Pancreatic Organoid Supplement C (250x).This product can be used to efficiently construct human pancreatic organoids.

HY-K6119

Mouse Intestinal Organoid Kit
MCE Mouse Intestinal Organoid Kit contains Mouse Intestinal Organoid Basal Medium A, Mouse Intestinal Organoid Supplement B (50x), Mouse Intestinal Organoid Supplement C (250x) and EDTA. This product can be used to efficiently construct mouse intestinal organoid.

HY-K6101

Human Breast Cancer Organoid Kit
MCE Human Breast Cancer Organoid Kit contains Breast Cancer Organoid Basal Medium A, Breast Cancer Organoid Supplement B (50x), Breast Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human breast cancer organoid.

HY-K6102

Human Lung Adenocarcinoma Organoid Kit
MCE Human Lung Adenocarcinoma Organoid Kit contains Lung Adenocarcinoma Organoid Basal Medium A, Lung Adenocarcinoma Organoid Supplement B (50x), Lung Adenocarcinoma Organoid Supplement C (250x). This product can be used to efficiently construct human lung adenocarcinoma organoid.

HY-K6104

Human Colorectal Cancer Organoid Kit
MCE Human Colorectal Cancer Organoid Kit contains Colorectal Cancer Organoid Basal Medium A, Colorectal Cancer Organoid Supplement B (50x), Colorectal Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human colorectal cancer organoid.

HY-K6105

Human Gastric Cancer Organoid Kit
MCE Human Gastric Cancer Organoid Kit contains Gastric Cancer Organoid Basal Medium A, Gastric Cancer Organoid Supplement B (50x), Gastric Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human gastric cancer organoid.

HY-K6107

Human Cervical Cancer Organoid Kit
MCE Human Cervical cancer Organoid Kit contains Cervical cancer Organoid Basal Medium A, Cervical cancer Organoid Supplement B (50x), Cervical cancer Organoid Supplement C (250x). This product can be used to efficiently construct human cervical cancer organoid.

HY-K6108

Human Esophageal Cancer Organoid Kit
MCE Human Esophageal Cancer Organoid Kit contains Esophageal Cancer Organoid Basal Medium A, Esophageal Cancer Organoid Supplement B (50x), Esophageal Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human esophageal cancer organoid.

HY-K6109

Human Endometrial Cancer Organoid Kit
MCE Human Endometrial Cancer Organoid Kit contains Endometrial Cancer Organoid Basal Medium A, Endometrial Cancer Organoid Supplement B (50x), Endometrial Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human endometrial cancer organoid.

HY-K6110

Human Pancreatic Cancer Organoid Kit
MCE Human Pancreatic Cancer Organoid Kit contains Pancreatic Cancer Organoid Basal Medium A, Pancreatic Cancer Organoid Supplement B (50x), Pancreatic Cancer Organoid Supplement C (250x). This product can be used to efficiently construct human pancreatic cancer organoid.

HY-K6113

Human Intestinal Organoid Kit
MCE Human Intestinal Organoid Kit contains Intestinal Organoid Basal Medium A, Intestinal Organoid Supplement B (50x), Intestinal Organoid Supplement C (250x), and Intestinal Organoid Supplement D (250x). This product can be used to efficiently construct human intestinal organoid.

HY-K6120

Mouse Colonic Organoid Kit
MCE Mouse Colonic Organoid Kit contains Colonic Organoid Basal Medium A, Colonic Organoid Supplement B (50x), Colonic Organoid Supplement C (250x), Colonic Organoid Supplement D (250x) and EDTA. This product can be used to efficiently construct mouse colonic organoid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11690

Oleandrigenin	Apocynaceae Structural Classification Natural Products Source classification Nerium indicum Mill. Plants	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

Species:	Human (11) Rhesus Macaque (1) Mouse (5) Rat (4)
Tag:	His (13) Tag Free (2) GST (2) Flag (1) Fc (5)
Source:	HEK293 (14) Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P78712

	*CD117/c-kit* Protein, Mouse (495a.a, HEK293, Fc)** CD117; SCFR; c-Kit; Kit	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is the recombinant mouse-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is 495 a.a., with molecular weight of ~110 kDa.

HY-P72752

	*CD117/c-kit* Protein, Human (HEK293, His)** Mast/stem cell growth factor receptor Kit; SCFR; PBT; CD117; Kit	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD117/c-kit Protein, Human (HEK293, His) is 495 a.a., with molecular weight of ~150 kDa.

HY-P72880

	*CD117/c-Kit* Protein, Mouse (HEK293, His)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CD117/c-Kit Protein, Mouse (HEK293, His) is 499 a.a., with molecular weight of 70-80 kDa.

HY-P702691

	*CD117/c-kit* Protein, Human (P10721-1, sf9)** Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor receptor Kit; C Kit; CD117; SCFR; p145 c-Kit; proto-oncogene c-Kit; piebald trait protein; soluble Kit variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit	Human	Sf9 insect cells

HY-P74337

CD117/c-kit Protein, Rat (HEK293, His)

Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl
Rat HEK293
HY-P74338

CD117/c-kit Protein, Rat (HEK293, Fc)

Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl
Rat HEK293

HY-P72480

	SCF Protein, Rat (His) Kit ligand; MGF; SCF; c-Kit ligand; sKitLG; Kitlg	Rat	E. coli
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (His) is the recombinant rat-derived SCF protein, expressed by E. coli , with C-6*His labeled tag. The total length of SCF Protein, Rat (His) is 164 a.a., with molecular weight of ~17 kDa.

HY-P74336

	*CD117/c-kit* Protein, Rhesus Macaque (HEK293, Fc)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Rhesus Macaque	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is 495 a.a., with molecular weight of 100-130 kDa.

HY-P74341

	*CD117/c-kit* Protein, Human (141a.a, His)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	E. coli
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (141a.a, His) is the recombinant human-derived CD117/c-kit protein, expressed by E. coli , with N-His labeled tag. The total length of CD117/c-kit Protein, Human (141a.a, His) is 141 a.a., with molecular weight of ~18 kDa.

HY-P72879

	*CD117/c-Kit* Protein, Mouse (523a.a, HEK293, Fc)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (523a.a, HEK293, Fc) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-Kit Protein, Mouse (523a.a, HEK293, Fc) is 499 a.a., with molecular weight of 100-120 kDa.

HY-P73495

	*CD117/c-kit* Protein, Human (P10721-2, HEK293, His)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag. The total length of CD117/c-kit Protein, Human (P10721-2, HEK293, His) is 491 a.a., with molecular weight of 75-85 kDa.

HY-P74339

	*CD117/c-kit* Protein, Human (P10721-2, HEK293, Fc)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is 491 a.a., with molecular weight of 93-115 kDa.

HY-P74340

	*CD117/c-kit* Protein, Human (433a.a, sf9, His-GST)** Mast/stem cell growth factor receptor Kit; SCFR; CD117; Kit; Sl	Human	Sf9 insect cells
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (433a.a, sf9, His-GST) is the recombinant human-derived CD117/c-kit protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CD117/c-kit Protein, Human (433a.a, sf9, His-GST) is 433 a.a., with molecular weight of ~68 kDa.

HY-P70757G

	GMP SCF Protein, Human (HEK293, His) Kit Ligand; MGF; SCF; c-Kit ligand; KitLG; sKitLG	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. GMP SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight of 30-50 kDa.

HY-P70781

	SCF Protein, Human 3 Publications Verification Kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-Kit ligand; KitLG; MGF; SCF	Human	E. coli
	SCF, Human, as a recombinant protein, plays essential roles in gametogenesis, melanogenesis and hematopoiesis. SCF, Human also plays an important role in nervous system.

HY-P70757

	SCF Protein, Human (HEK293, His) Kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-Kit ligand; KitLG; MGF; SCF	Human	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. SCF Protein, Human (HEK293, His) is the recombinant human-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Human (HEK293, His) is 189 a.a., with molecular weight (glycosylation form) of 30-50 kDa.

HY-P700148AF

	Animal-Free SCF Protein, Human (His) Kit Ligand; Mast Cell Growth Factor; MGF; Stem Cell Factor; SCF; c-Kit ligand; KitLG; MGF; SCF	Human	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and regulate a variety of cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members, and PLCG1, producing diacylglycerol and inositol 1,4,5-trisphosphate. Animal-Free SCF Protein, Human (His) is the recombinant human-derived animal-FreeSCF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free SCF Protein, Human (His) is 164 a.a., with molecular weight of ~19.4 kDa.

HY-P70555

	SCF Protein, Mouse (HEK293, His) FPH2; Kit ligand; Kitl; KitLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Mouse	HEK293
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse (HEK293, His) is the recombinant mouse-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Mouse (HEK293, His) is 164 a.a., with molecular weight of 19-35 kDa.

HY-P71130

	SCF Protein, Rat (HEK293, His) FPH2; Kit ligand; Kitl; KitLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SCFStem cell factor; SFc-Kit ligand; SLF; steel factor	Rat	HEK293
	Stem cell factor (SCF), as a key ligand of KIT, regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates signaling pathways involving phosphorylation events, key kinases (AKT1, RAS, RAF1, MAPK1/ERK2, MAPK3/ERK1), STAT family members, and PLCG1. SCF Protein, Rat (HEK293, His) is the recombinant rat-derived SCF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SCF Protein, Rat (HEK293, His) is 164 a.a., with molecular weight of 23-40 kDa.

HY-P70528

	SCF Protein, Mouse Kit ligand; Hematopoietic growth factor KL; Mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF	Mouse	E. coli
	SCF proteins are ligands for the KIT receptor-type protein tyrosine kinase and are critical for multiple cellular processes, including survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Binding to KIT activates multiple signaling pathways involving PIK3R1, AKT1, GRB2, RAS, RAF1, MAP kinase, STAT family members and PLCG1, producing signaling molecules. SCF Protein, Mouse is the recombinant mouse-derived SCF protein, expressed by E. coli , with tag free. The total length of SCF Protein, Mouse is 164 a.a., with molecular weight of ~16.0 kDa.

HY-P71118

	PFKFB1 Protein, Human (HEK293, His) 6-phosphofructo-2-kinase/fructose-2; 6-bisPhosphatase 1; 6PF-2-K/Fru-2; 6-P2ase liver isozyme; Fructose-2; 6-bisPhosphatase; PFKFB1; F6PK; PFRX	Human	HEK293
	PFKFB1 protein orchestrates the synthesis and degradation of fructose 2,6-bisphosphate, regulating cellular energy metabolism. Serving as a key enzyme, PFKFB1 modulates fructose 2,6-bisphosphate levels, impacting glycolysis and gluconeogenesis. Its dual role in both synthesis and breakdown is crucial for maintaining cellular energy homeostasis, ensuring adaptability to changing energy demands and environmental conditions. PFKFB1 Protein, Human (HEK293, His) is the recombinant human-derived PFKFB1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PFKFB1 Protein, Human (HEK293, His) is 470 a.a., with molecular weight of ~60.0 kDa.

Cat. No.	Product Name	Chemical Structure

HY-10873S

N-Desethyl Sunitinib-d5
N-Desethyl Sunitinib-d₅ is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].

HY-15463S

Imatinib-d8 1 Publications Verification
Imatinib-d₈ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-15463S1

Imatinib-d4
Imatinib-d₄ is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2].

HY-132451S

(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit

(R,S)-4-Hydroxy Cyclophosphamide-d₄ Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit[1].

HY-10981S1

Lenvatinib-d5
Lenvatinib-d₅ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

HY-10981S

Lenvatinib-d4
Lenvatinib-d₄ is the deuterium labeled Lenvatinib. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities[1][2].

HY-13904S

Flumatinib-d3
Flumatinib-d₃ is deuterium labeled Flumatinib. Flumatinib (HHGV678) is an orally available, selective inhibitor of Bcr-Abl. Flumatinib inhibits c-Abl, PDGFRβ and c-Kit with IC50s of 1.2 nM, 307.6 nM and 665.5 nM, respectively[1].

HY-13016S1

Cabozantinib-d4
Cabozantinib-d₄ is deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively.

HY-G0017S1

N-Desmethyl imatinib-d4
N-Desmethyl imatinib-d₄ is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d₄ (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .

HY-13342AS

Apatinib-d8 free base

Apatinib-d₈ (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4].

HY-10208S

Pazopanib-d6
Pazopanib-d₆ is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

HY-13016S

Cabozantinib-d6
Cabozantinib-d₆ is the deuterium labeled Cabozantinib. Cabozantinib is a potent multiple receptor tyrosine kinases (RTKs) inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively[1][2][3].

HY-10330S

Toceranib-d8
Toceranib-d₈ is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR, VEGFR, and Kit with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2].

HY-10331S1

Regorafenib-13C,d3
Regorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.

HY-10208S1

Pazopanib-13C,d3
Pazopanib- ¹³C,d₃ is the deuterium and ¹³C labeled Pazopanib[1]. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-12009S

Pazopanib-13C,d3 hydrochloride
Pazopanib- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-10230S

Midostaurin-d5
Midostaurin-d₅ is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

HY-15463S2

Imatinib-d3 hydrochloride

Imatinib-d₃ (hydrochloride) is the deuterium labeled Imatinib. Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-I0678S1

Regorafénib N-oxyde (M2)-13C,d3
Regorafénib N-oxyde (M2)- ¹³C,d₃ is the ¹³C- and deuterium labeled Regorafénib N-oxyde (M2). Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

HY-I0678S

Regorafénib N-oxyde-d3 (M2)
Regorafénib N-oxyde-d₃(M2) is the deuterium labeled Regorafénib N-oxyde M2[1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively[2].

HY-10201S2

Sorafenib-13C,d3

1 Publications Verification

Sorafenib- ¹³C,d₃ is the ¹³C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

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